Osteosarcoma (OSA) is a rapidly growing, destructive neoplasm of bone that accounts for 80% of all malignant bone tumors in dogs.9,10 Neoplasms of the skeleton are more common in dogs than in any other species. Primary bone tumors such as OSA are five times more common than metastatic skeletal neoplasms, and malignant tumors are more common than benign neoplasms.12
Breed, Age, and Sex Predisposition
Osteosarcoma is most common in giant and large breed dogs (90%) and is uncommon in small and medium breeds.13 Breeds especially predisposed to development of OSA include Saint Bernards, Rottweilers, Great Danes, Golden Retrievers, Irish setters, Doberman Pinschers, and Labrador retrievers. The mean age of occurrence is 7-1/2 years and incidence of OSA is slightly more common in males than females (1.2:1).10,13
Factors Influencing Tumor Development
Ionizing radiation, chemical carcinogens, foreign bodies (including metal implants, such as internal fixators, bullets, and bone transplants), and pre-existing skeletal abnormalities such as sites of healed fractures contribute to the development of OSA. In addition, there have been correlations with genetic predisposition to tumor development in certain family lines. Dogs with OSA have been found to have aberrations of the p53 tumor suppressor gene.11 In laboratory animals, both DNA viruses (polyomavirus and SV-40 virus) and RNA viruses (type C retroviruses) have been found to induce OSA.13
Sites of Origin and Metastasis
OSA can be found in both the appendicular and axial skeleton with the former being 3-4 times more common.10 This neoplasm originates most commonly in the metaphyses of the long bones of forelimbs, especially the distal radius and proximal humerus.